Histamine H3 Receptor - History

History

  • 1983 The H3 receptor is pharmacologically identified.
  • 1988 H3 receptor found to mediate inhibition of serotonin release in rat brain cortex.
  • 1997 H3 receptors shown to modulate ischemic norepinephrine release in animals.
  • 1999 H3 receptor cloned
  • 2000 H3 receptors called "new frontier in myocardial ischemia"
  • 2002 H3(-/-) mice (mice that do not have this receptor)

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