Hesperia may refer to:
- Hesperia, one of the Hesperides in Greek mythology
- Hesperia as "western land", a term sometimes applied to Italy and sometimes to the Iberian Peninsula
- Hesperia, also called Asterope, the wife or desired lover of Aesacus and daughter of the river Cebren
- Hesperia, California, a city in the United States
- Hesperia, Michigan, a village in the United States
- 69 Hesperia, an asteroid
- Hesperia Planum, a region of Mars
- Hesperia (butterfly) (branded skippers), a genus in the skippers (Hesperiidae), a butterfly family
- Hesperia (journal), an academic journal of Classical archaeology
- Hesperian Foundation an NGO which publishes Health guides