Hesketh may refer to:
- Baron Hesketh: the various Barons or Lords Hesketh, who lived at Easton Neston in Northamptonshire, England
- Lord Hesketh: the Conservative Party politician, formally titled Alexander Fermor-Hesketh, 3rd Baron Hesketh
- Hesketh Racing: the 1970s Formula One racing team, formed by Alexander Hesketh
- Hesketh Motorcycles: the former motorcycle brand, formed by Alexander Hesketh
- Lord Hesketh: the Conservative Party politician, formally titled Alexander Fermor-Hesketh, 3rd Baron Hesketh
- Victoria Hesketh, English musician better known by her stage name Little Boots
- Hesketh, Alberta: a Canadian hamlet
- Hesketh Bank: a small agricultural village in Lancashire
- Chris Hesketh, English rugby league footballer
- Sean Hesketh, English rugby league footballer
Read more about Hesketh: Etymology