Hermione may refer to:
- Hermione (given name), a female given name
- Hermione (mythology), only daughter of Menelaus and Helen in Greek mythology and original bearer of the name
- Hermione Granger, a main character in the Harry Potter novels and films
- HMS Hermione, seven ships of the Royal Navy
- French frigate Hermione (1779), a French frigate that carried La Fayette to join the American fight for independence in 1780
- USS Hawk (IX-14), formerly called Hermione
- 121 Hermione, an asteroid
- Cadmus et Hermione, an opera by Jean-Baptiste Lully
- Ermioni, a resort town in Greece originally called Hermione
- HERmione, a novel
- Hermiones, The Irminones, a group of early Germanic tribes
- Hermione (Tallulah, Louisiana), a Greek Revival building built in 1855 in Tallulah, Louisiana
- Hotspot Ecosystem Research and Man's Impact On European Seas (HERMIONE), an EU-funded deep-sea research project
- Letter to Hermione, a song from the album Space Oddity by David Bowie
- Sony Ericsson P990, a mobile phone codenamed Hermione
- A character in Shakespeare's The Winter's Tale