Herman Spieth (21 August 1905 – 20 October 1988) was an American zoologist and university administrator. He was the first chancellor of the University of California, Riverside from 1956 to 1964. Originally hired as a professor in the Life Sciences Department, he was responsible for administering UCR's change from a liberal arts college to a major research university. Spieth Hall at UCR is named after him.
Spieth served the University of California for 20 years, first as professor of Zoology and Chairman of the Department of Life Sciences at the newly founded UC campus at Riverside, and then as Provost and the first Chancellor of the Riverside campus, and finally as Chairman of the Department of Zoology at UC Davis. He retired in 1973 and devoted full time to his research on the evolutionary biology of Drosophila.