Function
HNF-4α is a nuclear transcription factor that binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene plays a role in development of the liver, kidney, and intestines . Alternative splicing of this gene results in multiple transcript variants.
HNF4A is required for the PXR and CAR-mediated transcriptional activation of CYP3A4.
The alkaloid berberine upregulates the expression of HNF4A.
Read more about this topic: Hepatocyte Nuclear Factor 4 Alpha
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