Hematologic Disease

Myeloid

Hemoglobinopathies (congenital abnormality of the hemoglobin molecule or of the rate of hemoglobin synthesis)
- Sickle-cell disease
- Thalassemia
- Methemoglobinemia
Anemias (lack of red blood cells or hemoglobin)
- Iron deficiency anemia
- Megaloblastic anemia
  - Vitamin B deficiency
    - Pernicious anemia
  - Folate deficiency
- Hemolytic anemias (destruction of red blood cells)
  - Genetic disorders of RBC membrane
    - Hereditary spherocytosis
    - Hereditary elliptocytosis
    - Congenital dyserythropoietic anemia
  - Genetic disorders of RBC metabolism
    - Glucose-6-phosphate dehydrogenase deficiency (G6PD)
    - Pyruvate kinase deficiency
  - Immune mediated hemolytic anemia (direct Coombs test is positive)
    - Autoimmune hemolytic anemia
      - Warm antibody autoimmune hemolytic anemia
        
        Idiopathic
        
        Systemic lupus erythematosus (SLE)
        
        Evans' syndrome (antiplatelet antibodies and hemolytic antibodies)
      - Cold antibody autoimmune hemolytic anemia
        
        Idiopathic cold hemagglutinin syndrome
        
        Infectious mononucleosis
        
        Paroxysmal cold hemoglobinuria (rare)
    - Alloimmune hemolytic anemia
      - Hemolytic disease of the newborn (HDN)
        
        Rh disease (Rh D)
        
        ABO hemolytic disease of the newborn
        
        Anti-Kell hemolytic disease of the newborn
        
        Rhesus c hemolytic disease of the newborn
        
        Rhesus E hemolytic disease of the newborn
        
        Other blood group incompatibility (RhC, Rhe, Kid, Duffy, MN, P and others)
    - Drug induced immune mediated hemolytic anemia
      - Penicillin (high dose)
      - Methyldopa
  - Hemoglobinopathies (where these is an unstable or crystalline hemoglobin)
  - Paroxysmal nocturnal hemoglobinuria (rare acquired clonal disorder of red blood cell surface proteins)
  - Direct physical damage to RBCs
    - Microangiopathic hemolytic anemia
    - Secondary to artificial heart valve(s)
- Aplastic anemia
  - Fanconi anemia
  - Diamond-Blackfan anemia
  - Acquired pure red cell aplasia
Decreased numbers of cells
- Myelodysplastic syndrome
- Myelofibrosis
- Neutropenia (decrease in the number of neutrophils)
- Agranulocytosis
- Glanzmann's thrombasthenia
- Thrombocytopenia (decrease in the number of platelets)
  - Idiopathic thrombocytopenic purpura (ITP)
  - Thrombotic thrombocytopenic purpura (TTP)
  - Heparin-induced thrombocytopenia (HIT)

Myeloproliferative disorders (Increased numbers of cells)
- Polycythemia vera (increase in the number of cells in general)
- Erythrocytosis (increase in the number of red blood cells)
- Leukocytosis (increase in the number of white blood cells)
- Thrombocytosis (increase in the number of platelets)
- Myeloproliferative disorder

Coagulopathies (disorders of bleeding and coagulation)
- Thrombocytosis
- Recurrent thrombosis
- Disseminated intravascular coagulation
- Disorders of clotting proteins
  - Hemophilia
    - Hemophilia A
    - Hemophilia B (also known as Christmas disease)
    - Hemophilia C
  - Von Willebrand disease
  - Disseminated intravascular coagulation
  - Protein S deficiency
  - Antiphospholipid syndrome
- Disorders of platelets
  - Thrombocytopenia
  - Glanzmann's thrombasthenia
  - Wiskott-Aldrich syndrome

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Hematologic Disease - Myeloid