HELO or Helo may refer to:
- Hello, in the Welsh language
- Hello, in the Malay language
- HELO, a command used in the Simple Mail Transfer Protocol
- Helo, the callsign for Karl Agathon in the television series Battlestar Galactica
- HELO, the Huddersfield Experimental Laptop Orchestra, based within the University of Huddersfield music department
- A helicopter