HDR may refer to:
- HDR, Inc., an American architectural and engineering firm
- Hard disk recorder
- Hevy Devy Records, a record label
- High Dose Rate, a treatment technique in radiotherapy
- High dynamic range imaging, digital imaging
- High dynamic range rendering, 3D image rendering
- Higher Degree by Research, a term for postgraduate education
- Homology-directed repair, a DNA repair system in the cells of mammals
- Hot Dry Rock, an experimental form of geothermal energy production
- Human Development Report, an annual UN publication
- Humanitarian daily ration, an air-dropped ration for disasters
- Habilitation à Diriger des Recherches, higher doctorate in France
- High Data Rate, the original name for the 1xEV-DO radio communications system