- Japan (1613)
- April 1613: Date Masamune receives permission from the Tokugawa Shogunate for the expedition and the building of a ship.
- 28 October 1613: Departure from Tsukinoura Bay.
- Americas (1613–1614)
- November 1613: Sighting of Cape Mendocino
- January 1614: Stop in Zacatula
- 25 January 1614: Arrival in Acapulco, New Spain
- 24 March 1614: Arrival in Mexico City
- Puebla
- Veracruz
- 10 June 1614: Boarding of a Spanish frigate at San Juan de Ulúa
- Havana
- Spain (1614–1615)
- 5 October 1614: Arrival at Sanlúcar de Barrameda in Spain
- Coria del Rio
- 21 October 1614: Arrival in Seville
- Córdoba
- Toledo
- Getafe
- 20 December 1614: Arrival in Madrid
- 30 January 1615: Meeting with King Philip III of Spain
- 17 February 1615: Baptism of Hasekura Tsunenaga
- Alcalá de Henares
- Daroca
- Zaragoza
- Fraga
- Lerida
- Igualada
- Barcelona
- France (1615)
- September 1615: Saint-Tropez
- Italy (1615–1616)
- Savona
- Genoa
- 18 October 1615: Arrival in Civitavecchia.
- 29 October 1615: Ceremony commemorating the mission's arrival in Rome.
- 3 November 1615: Meeting with Pope Paul V.
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- 23 November 1615: Reception of certificates of Honorary Citizenship by Hasekura Tsunenaga and four other Japanese members of the mission.
- Naples
- Rome
- Firenze
- Venice
- Firenze
- Livorno, by ship to Genoa
- Genoa
- Spain (1616)
- Barcelona
- Igualada
- Lerida
- Fraga
- Zaragoza
- Daroca
- Alcalá de Henares
- 17 April 1616: Return to Madrid.
- Getafe
- Toledo
- Córdoba
- Seville
- Coria del Rio
- June 1616: Departure from Spain, at Sanlúcar de Barrameda.
- Americas (1616–1618)
- Havana
- San Juan de Ulúa
- Veracruz
- Puebla
- Mexico City
- Departure from Acapulco, New Spain
- Philippines (1618–1620)
- 20 June 1618: Arrival in Manila, Philippines.
- Japan (1620)
- 22 September 1620: Arrival in Nagasaki, Japan
- 7 August 1622: Hasekura dies from illness
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