Halpern is a variation of the Jewish surname Heilprin and may refer to:
- Baruch Halpern, Jewish studies
- Charles Halpern, lawyer
- Charna Halpern, co–founder of ImprovOlympic
- Cheryl Halpern, chair of the Corporation for Public Broadcasting
- David Halpern, (1955– ), sprint canoer
- Diane F. Halpern, American psychologist
- Ida Halpern, (1910–1987), Austrian musicologist
- Jack Halpern (chemist), (1925– ), Polish chemist
- Jack Halpern (linguist), lexicographer
- Jake Halpern, (1975– ), American writer
- Jeff Halpern, (1976– ), American ice hockey player
- Joseph Halpern, computer science professor
- Justin Halpern, (1980-), American writer, author of Shit My Dad Says and I Suck at Girls
- Lily Halpern, American singer
- Mitch Halpern, (1967–2000), boxing referee
- Mortimer Halpern, (1909-2006), American Broadway stage manager
- Moyshe Leyb Halpern, (1886–1932), American Yiddish poet
- Paul Halpern, (1961– ), American science writer and physicist
- Yisroel Halpern (aka Yisroel Karduner), (?–1920), rabbi and Breslover Hasid