Gwydir may refer to:
- Australia
- Division of Gwydir, electoral division
- Gwydir by-election, 1989
- Gwydir Highway, New South Wales
- Gwydir River, New South Wales
- Gwydir Shire, New South Wales
- Gwydir Wetlands, New South Wales
- United Kingdom
- Gwydir Castle, Conwy, Wales
- Gwydir Forest, Conwy, Wales