GWC may refer to:
- Gambian Workers' Confederation, a trade union center in the Gambia
- General Watch Co Watch Sub-Holding Company of ASUAG, now integrated into the Swatch Group
- George Watson's College, an independent school in Edinburgh, Scotland
- George Wythe College
- Gnome Wave Cleaner, an audio restoration software application for Linux
- Golden West College
- Great West Conference, US college athletic conference
- Green Worker Cooperatives, a worker cooperative incubator in New York City