GWB is a three-letter abbreviation that may refer to:
- George W. Bush, 43rd President of the United States
- George Washington Bush, an early American settler
- George Washington Bridge, linking Washington Heights, Manhattan to Fort Lee, New Jersey
- George Washington Bridge Plaza in Fort Lee
- Great White Brotherhood, is a group of supernatural beings of great power in some Theosophical and New Age belief systems
- The Geochemist's Workbench, an interactive set of software tools for solving problems in aqueous geochemistry
- Gypsum wall board, a common artificial drywall used to finish construction of interior walls and ceilings
- Cosmic gravitational wave background, a relic of the Cosmic inflation.
- "Fuck You" (Lily Allen song), previously released under the titles "GWB", "Guess Who Batman" and "Get With the Brogram"