GUE may refer to:
- Gue, an extinct type of bowed lyre from the Shetland Isles, presumably resembling the extinct Norwegian Giga or extant Swedish Estonian Talharpa.
- Global Underwater Explorers, a SCUBA diving organization
- the Great Underground Empire, a kingdom in the fictional Zork universe
- in the Zork calendar, the name of the epoch
- Gaussian unitary ensemble in random matrix theory
- Left wing of the European United Left–Nordic Green Left (GUE-NGL) group in the European Parliament
- an abbreviation for Guernsey (rather than GG, GBG or GGY).
- Acronym for Geneon Universal Entertainment.