Guba may refer to:
- Guba, Azerbaijan (also spelled Quba), a city in and the capital of the Quba Rayon
- Guba Koricha, a woreda in Ethiopia
- Guba Lafto, a woreda in Ethiopia
- Guba (woreda), a woreda in Ethiopia
- Cyclone Guba, a tropical cyclone in Australasia, 2007
- Dávid Guba (born 1991), a Slovak football player
- Robert Guba Aisi, the current Permanent Representative of Papua New Guinea to the United Nations in New York
- Yuri Guba (Russian: Юрий Васильевич Губа; born 1984), a Russian professional football player
- a Russian word (Russian: Губа) for gulf, bay or fjord like in :
- Belushya Guba, a settlement in Arkhangelsk, Russia
- Kislaya Guba, a fjord on the Kola Peninsula near Murmansk, Russia
- Knyazhaya Guba (Russian: Княжая Губа), a rural locality in Kandalakshskiy District of Murmansk Oblast, Russia
- Ura-Guba, a rural locality in Kolsky District of Murmansk Oblast, Russia
- Sayda Guba, a rural locality in Gadzhiyevo municipality of Murmansk Oblast, Russia
- Tik-Guba, a rural locality in Apatity municipality of Murmansk Oblast, Russia
- Ura-Guba, a rural locality in Kolsky District of Murmansk Oblast, Russia
- Vayda-Guba, a rural locality in Pechengsky District of Murmansk Oblast, Russia
- a word for leprosy in some languages like Croatian, like in Jakub Štofik je guba
- a Hungarian prehistoric coat made of coarse knotted cloth
- a mourning chant sung by guests at an ancient Irish Aonach.