Uses
- Environments that use GTK+
- GNOME is based on GTK+, meaning that programs native to GNOME use GTK+
- Xfce is based on GTK+
- LXDE (Lightweight X11 Desktop Environment) is based on GTK+
- ROX Desktop is a lightweight desktop, with features from the GUI of RISC OS
- GPE Palmtop Environment
- Access Linux Platform (successor of the Palm OS PDA platform)
- Sugar is a desktop environment oriented towards children's education, which uses GTK+ and PyGTK
- KDE, though based on Qt, has integration with GTK+-based programs and themes (since version 4.2).
GTK+ programs do not require a desktop environment made with GTK+. If the required libraries are installed, a GTK+ program can run on top of other X11-based desktop environments or window managers; this includes Mac OS X if X11.app is installed (which is the default since the Leopard release). GTK+ can also run under Microsoft Windows, where it is used by some popular cross-platform applications like Pidgin and GIMP. wxWidgets, a cross-platform GUI toolkit, uses GTK+ for Linux operating systems. Other ports include DirectFB (used by the Debian installer, for example) and ncurses.
- Window managers
The following window managers use GTK+
- Aewm
- AfterStep
- Amaterus
- IceWM
- Metacity
- Mutter
- Sawfish
- Wmg
- Xfwm
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