Grubb is a family name and may refer to the following:
- Catharina Elisabet Grubb (1721–1788), Finnish industrialist
- Curtis Grubb (c. 1730-1789), American patriot and politician, majority owner and operator of the Cornwall Iron Works, son of Peter Grubb, the Works' founder
- Dale Grubb, member of the Indiana House of Representatives
- Davis Grubb (1919-1980), American writer
- Edward Grubb (Quaker) (1854-1939), English Quaker
- Edward Burd Grubb, Jr. (1841-1913), American Civil War commander, businessman and politician
- Evelyn Grubb, American human rights and veterans' rights activist
- Freddie Grubb (1887-1949), British road racing cyclist and businessman
- George Grubb, Lord Provost and ex officio Lord-Lieutenant of Edinburgh
- Henry Bates Grubb (1774-1823), founder of the Grubb iron empire, son of Peter Grubb, Jr.
- Howard Grubb (1844-1931), Irish telescope maker
- Ignatius Cooper Grubb (1841-1927), American politician, jurist and historian
- Jeff Grubb (born 1957), author and game designer
- Jehu Grubb (c. 1781-1854), American settler and member of the Ohio House of Representatives, unacknowledged son of Curtis Grubb
- Jennifer Grubb, American professional soccer player and coach
- John Grubb (Delaware settler) (1652-1708), early American settler and member of the Pennsylvania Provincial Assembly
- Johnny Grubb (born 1948), former Major League Baseball player
- Kevin Grubb (1978-2009), NASCAR driver
- Margaret Grubb (1907-1963?), first wife of Scientology founder L. Ron Hubbard
- Nathaniel Grubb (c. 1693–1760), mill owner and member of the Pennsylvania Colonial Assembly from 1749 to 1758
- Norman Grubb (1895-1993), missionary and General Secretary of the Worldwide Evangelization Crusade
- Peter Grubb (mason) (c. 1702-1754), founder of the Cornwall Iron Works and builder of the Cornwall Furnace in colonial Pennsylvania
- Peter Grubb, Jr. (1740-1786), American patriot, operator of the Cornwall Iron Works, and son of the above Peter Grubb
- Peter Grubb (zoologist) (1942-2006), British zoologist
- Peter J. Grubb (born 1935), British ecologist
- Robert Grubb (born 1950), Australian actor
- Sarah Pim Grubb (1746–1832), Irish businesswoman and Quaker benefactor
- Thomas Grubb (1800-1878), Irish optician
- Warner Norton Grubb (1900-1947), American petroleum executive and senior petroleum distribution officer with the U.S. Navy during World War II
- Wayne Grubb (born 1976), former NASCAR driver
- William Irwin Grubb (1862-1935), U.S. federal judge who struck down key portions of President Roosevelt’s New Deal
- A family of hobbits in J.R.R. Tolkien's fictional Middle-Earth