Grob Fragmentation

A Grob fragmentation, named for the Swiss chemist Cyril A. Grob, is an elimination reaction taking place when an electrofuge and nucleofuge are situated in positions 1 and 3 on an aliphatic chain. The reaction product is an electrofugal fragment (carbonium ion, acylium ion), an unsaturated fragment (alkene, alkyne, imine) and a nucleofugal fragment (leaving group such as tosyl, hydroxyl).

Grob fragmentation

Read more about Grob Fragmentation:  History, Reaction Mechanism, Scope

Other articles related to "grob fragmentation, grob, fragmentation":

Grob Fragmentation - Scope
... An example of a Grob-like fragmentation in organic synthesis is the expansion of the Wieland-Miescher ketone (1 in scheme 2) to Thapsigargin Scheme 2 ... Grob-like fragmentation in Thapsigargin synthesis Another example is an epoxy alcohol fragmentation reaction as part of the Holton Taxol total synthesis ... The Grob fragmentation has been applied in the synthesis of the fragrance muscenone (scheme 3) Scheme 3 ...