Grizzlies may refer to:
- Grizzly bear, a powerful bear that lives in the uplands of western North America
- Memphis Grizzlies (formerly the Vancouver Grizzlies), a basketball team of the National Basketball Association
- Ansbach Grizzlies, an American football team based at Ansbach, Germany
- Fairbanks Grizzlies, a professional Indoor Football League team from Fairbanks, Alaska
- Fresno Grizzlies, a minor league baseball team of the Pacific Coast League, the Triple-A associate of the San Francisco Giants
- Gateway Grizzlies, a minor league baseball team of the Frontier League
- Montana Grizzlies, college teams from the University of Montana
- Utah Grizzlies, an ice hockey team of the East Coast Hockey League
- An informal name for the Memphis Southmen, a team in the former World Football League
- Mascot for the sports teams of Northside High School (Fort Smith, Arkansas)