Griffiths is a surname with Welsh origins, as in Gruffydd ap Llywelyn Fawr. People called Griffiths recorded here include:
- Alan Griffiths (born 1952), Australian politician and businessman
- Alan Griffiths (cricketer) (born 1957), English cricketer
- Albert Griffiths (1871–1927), better known as Young Griffo, boxing champion
- Barri Griffiths (1982–), Welsh professional wrestler and former Gladiators competitor
- Bede Griffiths (1906–1993), British-born monk and missionary in India
- Bryn (Brynlyn) Griffiths, Welsh poet and writer
- Cecil Griffiths (1901–1945), British athlete
- Charles Griffiths, Australian politician
- Colin Griffiths (born 1983), English comedian, DJ, VJ and writer
- Ciaran Griffiths (born 1983), British actor, currently in Shameless
- Dan Griffiths (1857–1936), Welsh international rugby player
- David Griffiths, there are several people by this name
- Dean Griffiths (born 1980), Jamaican hurdler
- Dewi Griffiths (born 1931), Welsh television producer and radio host
- Eddie Griffiths, Australian fire fighter, World War I veteran and rugby league footballer
- Frances Griffiths: see Cottingley Fairies
- Fred Griffiths, South African rugby league footballer
- H. W. Griffiths (Henry W. Griffiths Jr.), Idaho railroad photographer
- Howard Griffiths (disambiguation)
- Ivor Griffiths (1918–1993), Welsh footballer
- Jemma Griffiths (1975–), better known as Jem, Welsh singer-songwriter
- Joel Griffiths (1979–), Australian soccer
- John Griffiths (Conservative politician), Leader of St Edmundsbury Borough Councl, Suffolk
- J. Gwyn Griffiths, poet, Egyptologist and Welsh nationalist political activist
- John Lewis Griffiths, Consul General of the United States to Britain
- John W. Griffiths (1809–1882), American naval architect
- Käte Bosse-Griffiths (1910–1998), German born Egyptologist and writer in the Welsh language
- Leigh Griffiths, Scottish footballer
- Linda Griffiths (1956–), Canadian actor and playwright
- Louise Griffiths, pop singer, songwriter and actress
- Lucy Griffiths (actress born 1919)
- Lucy Griffiths (actress born 1986)
- Marcia Griffiths (1949–) Jamaican singer
- Mike Griffiths, Welsh international rugby player
- Niall Griffiths (born 1966), English author
- Peter Griffiths, English politician
- Philip Jones Griffiths (1936–2008), Welsh photojournalist
- Philip Lewis Griffiths (1881–1945), Australian jurist
- Phillip Griffiths (born 1938), American mathematician
- Rachel Griffiths (born 1968), Australian actress
- Rhys Griffiths (footballer)
- Rhys Griffiths (rugby league)
- Richard Griffiths, British actor
- Robert Griffiths (disambiguation)
- Rowland Griffiths (1886–1914), Wales international rugby union player
- Ryan Griffiths (guitarist) (1978–)
- Sandi Griffiths (born 1945), American singer
- Selina Griffiths, British actress
- Terry Griffiths (born 1947), retired Welsh snooker player
- Terry Griffiths (politician) (1944-2009), New South Wales politician
- Trevor Griffiths (born 1935), English dramatist
- Tuffy Griffiths, boxer