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- Marcus Griffin
- Marvin Griffin
- Marion Mahony Griffin
- Merv Griffin (1925–2007), entertainer, talk show host, and creator of the television game shows Jeopardy! and Wheel of Fortune
- Michael D. Griffin, the Administrator of NASA
- Michael F. Griffin, anti-abortion activst who killed David Gunn
- Michael Griffin (American football) (born 1985), American football player
- Montell Griffin, professional boxer
- Morgan Griffin, professional actress starred in Nickelodeon show The Sleepover Club Series 2 as Charlie Anderson
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