Greyed - Genetics and Biochemistry of Hair Color

Genetics and Biochemistry of Hair Color

See also: Human genetic variation, Race and genetics, and Human genetic clustering

Two types of pigment give hair its color: eumelanin and pheomelanin. Pheomelanin colors hair orange and yellow. Eumelanin, which has two subtypes of black or brown, determines the darkness of the hair color. A low concentration of brown eumelanin results in blond hair, whereas a higher concentration of brown eumelanin will color the hair brown. High amounts of black eumelanin result in black hair, while low concentrations give gray hair. All humans have some pheomelanin in their hair.

Pheomelanin is more chemically stable than black eumelanin, but less chemically stable than brown eumelanin, so it breaks down more slowly when oxidized. This is why bleach gives darker hair a reddish tinge during the artificial coloring process. As the pheomelanin continues to break down, the hair will gradually become orange, then yellow, and finally white.

The genetics of hair colors are not yet firmly established. According to one theory, at least two gene pairs control human hair color.

One phenotype (brown/blond) has a dominant brown allele and a recessive blond allele. A person with a brown allele will have brown hair; a person with no brown alleles will be blond. This explains why two brown-haired parents can produce a blond-haired child.

The other gene pair is a non-blond/blond pair, where the non-blond allele (which suppresses production of pheomelanin) is dominant and the allele for blond hair is recessive. A person with two copies of the blond-haired allele will have blond hair, but it will be either blondish or bright blond orange depending on whether the first gene pair gives brown or blond hair, respectively.

The two-gene model does not account for all possible shades of brown, blond, or red (for example, platinum blond versus dark blond/light brown), nor does it explain why hair color sometimes darkens as a person ages. Several gene pairs control the light versus dark hair color in a cumulative effect. A person's genotype for a multifactorial trait can interact with environment to produce varying phenotypes (see quantitative trait locus).