- Valeen Tippetts Avery, American biographer and historian
- Walter Breuning (1896–2011), once the oldest man in the world
- Mal Bross, National Football League player
- James R. Browning, judge and former Chief Judge on the United States Court of Appeals for the Ninth Circuit and former Clerk of the United States Supreme Court
- Dorothy Coburn, silent movie actress
- Walter Coy, actor
- Brian Coyle, Minnesota community leader and gay activist
- Scott Davis, two-time U.S. Figure Skating Championships gold medalist
- Dave Dickenson, Canadian Football League quarterback
- Ian Joe Dutch, longboarder, filmmaker, artist
- Patrick Dwyer, National Hockey League player
- Cory Fong, North Dakota State Tax Commissioner
- Ted Geoghegan, horror filmmaker
- John Gibbons, Major League Baseball manager
- Paris Gibson, U.S. Senator, city founder
- Missy Gold, child actress on Benson
- Melony G. Griffith, member of the Maryland House of Delegates
- A. B. Guthrie, Jr., Pulitzer Prize-winning author of The Way West
- Malcolm Hancock, magazine cartoonist
- Charles S. Hartman, United States Representative from Montana
- Paul G. Hatfield, Federal District Court Judge (1979 to 2000), former U.S. Senator, former Chief Justice of the Montana Supreme Court, former Montana state District Court Judge
- Lester Hogan, pioneer in microwave & semiconductor technology
- Joseph Kinsey Howard, author and historian
- Alma Smith Jacobs - first African American Montana State Librarian
- Jay L. Johnson, U.S. Navy admiral, Chief of Naval Operations
- Edward McKnight Kauffer, early 20th century graphic designer and poster artist
- Pert Kelton, actress, the original Alice Kramden on The Honeymooners
- Ryan Leaf, National Football League quarterback
- Barbara Luddy, American actress
- Howard Lyman, vegetarian activist
- Einar Axel Malmstrom, U.S. Air Force colonel
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- Mike Mansfield, U.S. Representative, Senator, longest-ever serving Senate majority leader& U.S. Ambassador to Japan
- Linda McDonald, drummer in all-girl metal band Phantom Blue
- Leonard McEwan, former member of the Wyoming Supreme Court, born in Great Falls
- Cyra McFadden, writer
- Hugh Mitchell, served as a member of the United States Senate from 1945 to 1946 and as a member of the United States House of Representatives from 1949 to 1953 for the state of Washington.
- Gerald R. Molen, Academy Award–winning film producer
- George Montgomery, actor, painter, sculptor & stuntman, born in nearby Brady
- Matt Morrison, Fox Sports Net sportscaster
- John Misha Petkevich, U.S. Figure Skating Championships gold medalist
- Andrew Nelson, Japanese-language lexicographer
- Tom Neville, National Football League player
- Victoria Paris, adult film actress
- Tera Patrick, adult film actress
- Charles Nelson Pray, former U.S. Representative from Montana
- Charley Pride, country singer
- Traver Rains, one half of the New York fashion design duo Heatherette
- Merle Greene Robertson, artist, art historian, archaeologist & Mayan researcher
- William V. Roth, Jr., U.S. Representative & Senator from Delaware
- Charles Marion Russell, western artist
- Brian Salonen, tight end for the Dallas Cowboys
- Wallace Stegner, Pulitzer Prize-winning author of Angle of Repose
- Haila Stoddard, American actor, writer, producer and director
- Edward L. Thrasher, Los Angeles, California, City Council member between 1931 and 1942, born in Great Falls
- Al Ullman, United States Congressman from Oregon
- Reggie Watts, comedian, musician, performance artist
- John Warner, justice of the Montana Supreme Court
- Irving Weissman, scientist
- Brett Weldele, comic book artist, Southland Tales graphic novels
- Bill Zadick, wrestler
- Mike Zadick, wrestler
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