GRC can mean:
- Ancient Greek (ISO 639-3 language code grc)
- The country Greece (ISO 3166-1 alpha-3 country code GRC)
- Genome Reference Consortium
- General Revenue Corporation (United States)
- GE Global Research Center, the research and development wing of General Electric.
- George Rogers Clark, American Revolutionary War general
- Gibson Research Corporation
- Glasgow Rowing Club
- Glass fiber reinforced concrete (GFRC)
- Glenn Research Center - a NASA research center in Cleveland, Ohio
- Governance, Risk Management, and Compliance
- Grassroots Radio Coalition
- Group Representation Constituency in Singapore
- Gulf Research Center
- Guthy-Renker Corporation
- Royal Canadian Mounted Police (Gendarmerie Royale du Canada in French)
- Gender Recognition Certificate, a certificate issued under the Gender Recognition Act 2004 of the United Kingdom
- Ghana Railway Corporation