GPM may refer to:
- GPM (software), a mouse server for the console and xterm
- Graphical path method, mathematically-based algorithm used in project management
- Gallons per minute, a unit of volumetric flow rate
- Gallons per mile, a unit of fuel efficiency
- General Purpose Macrogenerator, an early macro processor
- Global Marshall Plan, specific ideas on how to save the global environment
- Global Precipitation Measurement, a Japan Aerospace Exploration Agency project to measure global rainfall
- Graduated payment mortgage, a type of loan
- Grand Prix Masters, an auto racing series for retired Formula One drivers
- Green Project Management, GPM, a project management organization that promotes sustainability through P5, Accreditation, and PRiSM
- Gross profit margin, a calculation of revenue and cost of products