GPF can refer to:
- General Protection Fault, an error that can occur on the Intel x86 architecture
- Global Policy Forum, a non-governmental organization.
- The webcomic, General Protection Fault.
- Gallon Per Flush, as shown on American urinals "1 gpf / 3.7 lpf" (liters per flush)
- Grand Prix of Figure Skating Final, a figure skating competition.
- Grande Puissance, Filloux, a French heavy artillery gun.
- Global Peace Festival, a series of international celebrations with the motto of "One Family Under God."