Gordo, the Portuguese and Spanish word for fat (adj.), may refer to:
- Gordo (space monkey), the first monkey to travel beyond Earth's orbit
- Gordo, Alabama, USA
- Gordo (comic strip) a comic strip created by Gus Arriola
- Gordo, a spiked invincible enemy in the Kirby series of video games
- Eddy Gordo, a fictional character from the series of fighting games Tekken
- Leroy Gordon "Gordo" Cooper, an American astronaut
- David "Gordo" Gordon, a character from the Disney sitcom Lizzie McGuire
- Gordo, a gluttonous Black Pirate in Skies of Arcadia
- Gordo, an undead abomination in the Warcraft Universe
- Gordo, another name for the Muscat of Alexandria grape
- Gordo, a fictional character from the anime series Beyblade V-Force