Gonadotropin-releasing Hormone Agonist - Agonists With Double and Single Substitutions

Agonists With Double and Single Substitutions

GnRH agonists are synthetically modeled after the natural GnRH decapeptide with specific amino acid substitutions typically in position 6 and 10. These substitutions inhibit rapid degradation. Agonists with 2 substitutions include:

  1. leuprolide (Lupron, Eligard)
  2. buserelin (Suprefact, Suprecor)
  3. nafarelin (Synarel) (only a single substitution at position 6)
  4. histrelin (Supprelin LA, Vantas)
  5. goserelin (Zoladex)
  6. deslorelin (Suprelorin, Ovuplant)

Triptorelin is an agonist with only a single substitution at position 6. In India,Dr. Reddy's Laboratories has launched recently Triptorelin under the brand name "Pamorelin LA".

  • Leuprolide

  • Buserelin

  • Nafarelin

  • Histrelin

  • Goserelin

  • Deslorelin

Read more about this topic:  Gonadotropin-releasing Hormone Agonist

Famous quotes containing the words double and/or single:

    “He does me double wrong
    That wounds me with the flatteries of his tongue.”
    —William Shakespeare (1564–1616)

    “[The] elderly and timid single gentleman in Paris ... never drove down the Champs Elysees without expecting an accident, and commonly witnessing one; or found himself in the neighborhood of an official without calculating the chances of a bomb. So long as the rates of progress held good, these bombs would double in force and number every ten years.”
    —Henry Brooks Adams (1838–1918)