Isozymes
In humans, there are two paralogous isozymes of glycogen synthase:
| isozyme | tissue distribution | gene |
|---|---|---|
| glycogen synthase 1 | muscle and other tissues | GYS1 |
| glycogen synthase 2 | liver | GYS2 |
The liver enzyme expression is restricted to the liver, whereas the muscle enzyme is widely expressed. Liver glycogen serves as a storage pool to maintain the blood glucose level during fasting, whereas muscle glycogen synthesis accounts for disposal of up to 90% of ingested glucose. The role of muscle glycogen is as a reserve to provide energy during bursts of activity.
|
|
||||||||||||||||||||||||||||||||||||||||||||
Read more about this topic: Glycogen Synthase