Alpha Gliadin 31-43
Gluten bears an innate response peptide (IRP) found on α-9 gliadin, at positions 31-43 and on α-3, 4, 5, 8, and 11 gliadins. The IRP lies within a 25 amino-acid long region that is resistant to pancreatic proteases. The 25mer is also resistant to Brush border membrane peptidases of the small intestine in coeliacs. IRP induced the rapid expression of interleukin 15 (IL15) and other factors. Thus IRP activates the immune system. Studies show that, while in normal individuals the peptide is trimmed over time to produce inactive peptide, in celiacs a 19mer may lose a residue from one end or the other, after prolonged incubation that 50% remains intact.
Read more about this topic: Gluten Immunochemistry, Innate Immunity
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