Glutamate Hypothesis of Schizophrenia - Animal Models

Animal Models

A research done on mice in early 2009 has shown that when the neuregulin-1\ErbB post-synaptic receptor genes are deleted, the dendritic spines of glutamate neurons initially grow, but break down during later development. It was found that symptomic similarities to the disease matched schizophrenia upon expression.(symptoms such as disturbed social function, inability to adapt to predictable future stressors) This parallels the time delay for symptoms setting in with schizophrenic humans who usually appear to show normal development until early adulthood.

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