Glutamate Dehydrogenase 1
Gene Ontology | |
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Molecular function | • glutamate dehydrogenase (NAD+) activity • glutamate dehydrogenase • protein binding • ATP binding • GTP binding • identical protein binding • ADP binding • NAD+ binding • leucine binding |
Cellular component | • cytoplasm • mitochondrion • mitochondrial matrix |
Biological process | • glutamate biosynthetic process • glutamate catabolic process • cellular amino acid biosynthetic process • positive regulation of insulin secretion • cellular nitrogen compound metabolic process • small molecule metabolic process |
Sources: Amigo / QuickGO |
88.81 – 88.85 Mb
34.31 – 34.35 Mb
GLUD1 (Glutamate dehydrogenase 1) is a mitochondrial matrix enzyme, with a key role in the nitrogen and glutamate (Glu) metabolism and the energy homeostasis. GLUD1 is expressed at high levels in liver, brain, pancreas and kidney, but not in muscle. In the pancreatic cells, GLUD1 is thought to be involved in insulin secretion mechanisms. In nervous tissue, where Glu is present in concentrations higher than in the other tissues, GLUD1 appears to function in both the synthesis and the catabolism of Glu and perhaps in ammonia detoxification.
Read more about Glutamate Dehydrogenase 1: Structure, Function, Regulation, Gene