Glutamate Dehydrogenase 1

Glutamate Dehydrogenase 1

Identifiers Symbols GLUD1; GDH; GDH1; GLUD External IDs OMIM: 138130 MGI: 95753 HomoloGene: 55885 GeneCards: GLUD1 Gene EC number 1.4.1.3

Gene Ontology
Molecular function	• glutamate dehydrogenase (NAD+) activity • glutamate dehydrogenase • protein binding • ATP binding • GTP binding • identical protein binding • ADP binding • NAD+ binding • leucine binding
Cellular component	• cytoplasm • mitochondrion • mitochondrial matrix
Biological process	• glutamate biosynthetic process • glutamate catabolic process • cellular amino acid biosynthetic process • positive regulation of insulin secretion • cellular nitrogen compound metabolic process • small molecule metabolic process
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 2746 14661 Ensembl ENSG00000148672 ENSMUSG00000021794 UniProt P00367 P26443 RefSeq (mRNA) NM_005271.3 NM_008133.4 RefSeq (protein) NP_005262.1 NP_032159.1 Location (UCSC) Chr 10:
88.81 – 88.85 Mb Chr 14:
34.31 – 34.35 Mb PubMed search

GLUD1 (Glutamate dehydrogenase 1) is a mitochondrial matrix enzyme, with a key role in the nitrogen and glutamate (Glu) metabolism and the energy homeostasis. GLUD1 is expressed at high levels in liver, brain, pancreas and kidney, but not in muscle. In the pancreatic cells, GLUD1 is thought to be involved in insulin secretion mechanisms. In nervous tissue, where Glu is present in concentrations higher than in the other tissues, GLUD1 appears to function in both the synthesis and the catabolism of Glu and perhaps in ammonia detoxification.