Glutaconyl-Co A Decarboxylase

Glutaconyl-Co A Decarboxylase

In enzymology, a glutaconyl-CoA decarboxylase (EC 4.1.1.70) is an enzyme that catalyzes the chemical reaction

4-carboxybut-2-enoyl-CoA but-2-enoyl-CoA + CO₂

Hence, this enzyme has one substrate, 4-carboxybut-2-enoyl-CoA, and two products, but-2-enoyl-CoA and CO₂.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 4-carboxybut-2-enoyl-CoA carboxy-lyase (but-2-enoyl-CoA-forming). Other names in common use include glutaconyl coenzyme A decarboxylase, pent-2-enoyl-CoA carboxy-lyase, and 4-carboxybut-2-enoyl-CoA carboxy-lyase. This enzyme participates in benzoate degradation via coa ligation and butanoate metabolism.