Development
Glatiramer acetate was originally discovered by Prof. Michael Sela, Prof. Ruth Arnon and Dr. Dvora Teitelbaum at the Weizmann Institute of Science in Rehovot, Israel. The efficacy and safety of glatiramer acetate were demonstrated in three main clinical trials. The first trial, led by Professor Murray Bornstein, was performed in a single center, double-blind, placebo controlled trial and included 50 patients.Template:Bornstein MB, Miller A, Slagle S, Weitzman M, Crystal H, Drexler E, Keilson M, Merriam A, Wassertheil-Smoller S, Spada V, et al.N Engl J Med. 1987 Aug 13;317(7):408-14. The second trial was a two-year, multi-center, randomized, double-blind, placebo controlled trial and was performed in eleven United States centers involving 251 patients. This study was led by Professor Kenneth Johnson, Chairman of the Department of Neurology, University of Maryland Medical Center, Baltimore.Template:Johnson KP, Brooks BR, Cohen JA, Ford CC, Goldstein J, Lisak RP, Myers LW,Panitch HS, Rose JW, Schiffer RB.Neurology. 1995 Jul;45(7):1268-76. The third trial, a double-blind, multi-center, multi-country MRI study, involved 29 MS Centers in six European countries and Canada, with the participation of 239 patients. This study was led by Professor G. Comi, Department of Neuroscience, San Raffaele Hospital, the University of Milan.Template:Comi G, Filippi M, Wolinsky JS.Ann Neurol. 2001 Mar;49(3):290-7.
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