Development
Glatiramer acetate was originally discovered by Prof. Michael Sela, Prof. Ruth Arnon and Dr. Dvora Teitelbaum at the Weizmann Institute of Science in Rehovot, Israel. The efficacy and safety of glatiramer acetate were demonstrated in three main clinical trials. The first trial, led by Professor Murray Bornstein, was performed in a single center, double-blind, placebo controlled trial and included 50 patients.Template:Bornstein MB, Miller A, Slagle S, Weitzman M, Crystal H, Drexler E, Keilson M, Merriam A, Wassertheil-Smoller S, Spada V, et al.N Engl J Med. 1987 Aug 13;317(7):408-14. The second trial was a two-year, multi-center, randomized, double-blind, placebo controlled trial and was performed in eleven United States centers involving 251 patients. This study was led by Professor Kenneth Johnson, Chairman of the Department of Neurology, University of Maryland Medical Center, Baltimore.Template:Johnson KP, Brooks BR, Cohen JA, Ford CC, Goldstein J, Lisak RP, Myers LW,Panitch HS, Rose JW, Schiffer RB.Neurology. 1995 Jul;45(7):1268-76. The third trial, a double-blind, multi-center, multi-country MRI study, involved 29 MS Centers in six European countries and Canada, with the participation of 239 patients. This study was led by Professor G. Comi, Department of Neuroscience, San Raffaele Hospital, the University of Milan.Template:Comi G, Filippi M, Wolinsky JS.Ann Neurol. 2001 Mar;49(3):290-7.
Read more about this topic: Glatiramer Acetate
Famous quotes containing the word development:
“The experience of a sense of guilt for wrong-doing is necessary for the development of self-control. The guilt feelings will later serve as a warning signal which the child can produce himself when an impulse to repeat the naughty act comes over him. When the child can produce his on warning signals, independent of the actual presence of the adult, he is on the way to developing a conscience.”
—Selma H. Fraiberg (20th century)
“On fields all drenched with blood he made his record in war, abstained from lawless violence when left on the plantation, and received his freedom in peace with moderation. But he holds in this Republic the position of an alien race among a people impatient of a rival. And in the eyes of some it seems that no valor redeems him, no social advancement nor individual development wipes off the ban which clings to him.”
—Frances Ellen Watkins Harper (1825–1911)
“The development of civilization and industry in general has always shown itself so active in the destruction of forests that everything that has been done for their conservation and production is completely insignificant in comparison.”
—Karl Marx (1818–1883)