People
- William Ewart Gladstone (1809–1898), Prime Minister of the United Kingdom four times between 1868 and 1894
- Gladstone baronets, members of the extended family of William Ewart Gladstone
- Sir John Gladstone, 1st Baronet (1764–1851), businessman and Member of Parliament (MP), father of William Ewart Gladstone
- Sir Thomas Gladstone, 2nd Baronet (1804–1889), MP, elder brother of William Ewart Gladstone
- John Neilson Gladstone (1807–1863), MP and brother of William Ewart Gladstone
- Catherine Gladstone (1812–1900), wife of William Ewart Gladstone
- John Hall Gladstone (1827–1902), British chemist
- William Henry Gladstone (1840–1892), MP and classical musician, eldest son of William Ewart Gladstone
- Henry Neville Gladstone, 1st Baron Gladstone of Hawarden (1852–1935), son of William Ewart Gladstone
- Herbert Gladstone, 1st Viscount Gladstone (1854–1930), Home Secretary 1905–1910 and Governor-General of South Africa 1910–1914; youngest son of William Ewart Gladstone
- Sir William Gladstone, 7th Baronet (born 1925), Chief Scout of the United Kingdom, 1972–1982
- Steve Gladstone, American rowing coach
- Gladstone Small (born 1961), former Warwickshire and England cricketer
- Gladstone (humorist), American humorist, columnist for Asylum and creator of Hate By Numbers.
- Gladstone Pereira della Valentina (born 1985), Brazilian footballer
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