Girolamo is an Italian variant of the name Hieronymus. Its English equivalent is Jerome.
It may refer to:
- Girolamo Cardano (1501–1576), Italian Renaissance mathematician, physician, astrologer and gambler
- Girolamo da Cremona (fl. 1451-1483), Italian Renaissance painter
- Girolamo Fracastoro (1478–1553), Italian physician, scholar, poet and atomist
- Girolamo Frescobaldi (1583–1643), Italian musician
- Girolamo Masci (1227–1292), Pope Nicholas IV (1288–1292)
- Girolamo Riario (1443–1488), Lord of Imola and Forlì
- Girolamo Romani (1485–1566), Italian High Renaissance painter
- Girolamo Savonarola (1452–1498), Italian Dominican priest and leader of Florence
- Girolamo Tiraboschi (1731–1794), Italian literary critic
- Girolamo da Treviso (1508–1544), Italian Renaissance painter
- Girolamo Zanchi (1516–1590), Italian Protestant Reformation clergyman and educator
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