Germaine may refer to:
- Germaine Cousin (1579-1601), French saint
- Germaine Greer (born 1939), feminist writer and academic
- Germaine Koh (born 1967), Malaysian-born Canadian artist
- Germaine Krull (1897-1985), photographer
- Germaine Tailleferre (1892-1983), French composer
- Germaine (olive), an olive grown in Corsica
- SS Empire Adventure, a cargo ship which carried the name Germaine L D between 1924 and 1931
Germaine is the name of two communes in France:
- Germaine, Aisne
- Germaine, Marne