George II may refer to:
- George II of Abkhazia (916–960)
- Patriarch George II of Alexandria (1021–1051)
- George II of Georgia (1072–1089)
- Yuri II of Vladimir or George II (1189–1238)
- George II of Bulgaria (before 1307-1322)
- George II, Prince of Anhalt-Dessau (1454-1509)
- George II of Kakheti (1464–1513)
- George II of Imereti (1565-1585)
- George II, Landgrave of Hesse-Darmstadt (1605–1661)
- George II of Great Britain (1683–1760)
- George II of Greece (1890–1947)