George Henderson may refer to:
- George Henderson (Australian politician) (1857–1933), Australian politician
- George Henderson (architect) (1846–1905), Scottish architect
- George Henderson (footballer) (1880–1930), Scottish footballer
- Geordie Henderson (1897–1953), Scottish footballer
- George Henderson (Manitoba politician) (1916–2008), former MLA in Manitoba
- George Henderson (mayor), mayor of Cumberland, Maryland, 1932–1934
- George Henderson (Northern Ireland politician), former Member of the Northern Ireland Parliament for Antrim
- George Henderson (scholar) (1866–1912), Gaelic scholar
- George Henderson (Prince Edward Island politician) (born 1935), former Member of Parliament in Canada
- George Henderson, father of the family in the 1987 film Harry and the Hendersons portrayed by John Lithgow
- George Henderson (River City)
- George Henderson (bishop) (1921–1996), Episcopal bishop and Primus in Scotland
- George Francis Robert Henderson (1854–1903), British soldier and military author
- George R. Henderson (1893–1964), World War II-era officer in United States Navy
- George R. Henderson Medal, given by the Franklin Institute for improvements to railway engineering
- George Stuart Henderson (1893–1920), recipient of the Victoria Cross
- George Washington Henderson, president of Straight University, New Orleans
- George Wylie Henderson (1904–1965), American author of the Harlem Renaissance
- Krazy George Henderson (born 1944), American cheerleader
- George Henderson (GC), British recipient of the George Cross