History
In 1974 Rudolf Jaenisch created the first genetically modified animal by inserting a DNA virus into an early-stage mouse embryo and showing that the inserted genes were present in every cell. However the mice did not pass the transgene to their offspring. In 1981 the laboratories of Frank Ruddle from Yale, Frank Constantini and Elizabeth Lacy from Oxford, and Ralph Brinster and Richard Palmiter from University of Pennsylvania and University of Washington injected purified DNA into a single-cell mouse embryo and showed transmission of the genetic material to subsequent generations. During the early eighties the technology used to generate genetically modified mice was improved into a tractable and reproducible method.
Read more about this topic: Genetically Modified Mouse
Famous quotes containing the word history:
“The disadvantage of men not knowing the past is that they do not know the present. History is a hill or high point of vantage, from which alone men see the town in which they live or the age in which they are living.”
—Gilbert Keith Chesterton (1874–1936)
“History has neither the venerableness of antiquity, nor the freshness of the modern. It does as if it would go to the beginning of things, which natural history might with reason assume to do; but consider the Universal History, and then tell us,—when did burdock and plantain sprout first?”
—Henry David Thoreau (1817–1862)
“The foregoing generations beheld God and nature face to face; we, through their eyes. Why should not we also enjoy an original relation to the universe? Why should not we have a poetry and philosophy of insight and not of tradition, and a religion by revelation to us, and not the history of theirs?”
—Ralph Waldo Emerson (1803–1882)