History
In 1974 Rudolf Jaenisch created the first genetically modified animal by inserting a DNA virus into an early-stage mouse embryo and showing that the inserted genes were present in every cell. However the mice did not pass the transgene to their offspring. In 1981 the laboratories of Frank Ruddle from Yale, Frank Constantini and Elizabeth Lacy from Oxford, and Ralph Brinster and Richard Palmiter from University of Pennsylvania and University of Washington injected purified DNA into a single-cell mouse embryo and showed transmission of the genetic material to subsequent generations. During the early eighties the technology used to generate genetically modified mice was improved into a tractable and reproducible method.
Read more about this topic: Genetically Modified Mouse
Famous quotes containing the word history:
“It takes a great deal of history to produce a little literature.”
—Henry James (1843–1916)
“This above all makes history useful and desirable: it unfolds before our eyes a glorious record of exemplary actions.”
—Titus Livius (Livy)
“All history is a record of the power of minorities, and of minorities of one.”
—Ralph Waldo Emerson (1803–1882)