GFF Versions
GFF Version 2 has a number of deficiencies, notably that it can only represent two-level feature hierarchies and thus cannot handle the three-level hierarchy of gene → transcript → exon. GFF3 addresses this and other deficiencies. For example, it supports arbitrarily many hierarchical levels, and gives specific meanings to certain tags in the attributes field.
The Gene transfer format (GTF) is a refinement of GFF Version 2 and is sometimes referred to as GFF2.5.
Read more about this topic: General Feature Format
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“The assumption must be that those who can see value only in tradition, or versions of it, deny man’s ability to adapt to changing circumstances.”
—Stephen Bayley (b. 1951)