GDF may stand for:
- Gaz de France
- General Data Format for Biomedical Signals
- Geographic Data Files
- Geological disposal facility for nuclear waste
- Global Defence Force, a video game
- Global Development Finance, a World Bank database
- Gluten and Dairy Free
- Global Delivery Framework (IBM)
- Great Dun Fell, a radar station in Cumbria, England
- Growth and differentiation factor, a subfamily of proteins belonging to the transforming growth factor beta superfamily
- Guides de France
- Guyana Defence Force