Gallium 67 Scan - Mechanism

Mechanism

The body generally handles Ga3+ as though it were ferric iron (Fe-III), and thus the free isotope ion is bound (and concentrates) in areas of inflammation, such as an infection site, and also areas of rapid cell division. Gallium (III) (Ga+3) binds to transferrin, leukocyte lactoferrin, bacterial siderophores, inflammatory proteins, and cell-membranes in neutrophils, both living and dead.

This relatively nonspecific gallium binding allows sites with tumor, inflammation, and both acute and chronic infection to be imaged by nuclear scan techniques.

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