GAB2

GAB2

Identifiers Symbols GAB2; KIAA0571 External IDs OMIM: 606203 MGI: 1333854 HomoloGene: 69067 GeneCards: GAB2 Gene

Gene Ontology
Molecular function	• transmembrane receptor protein tyrosine kinase adaptor activity • SH3/SH2 adaptor activity • protein binding • phosphatidylinositol-3,4,5-trisphosphate binding • phosphatidylinositol-3,4-bisphosphate binding
Cellular component	• cytoplasm • cytosol • plasma membrane
Biological process	• transmembrane receptor protein tyrosine kinase signaling pathway • positive regulation of cell proliferation • osteoclast differentiation • positive regulation of mast cell degranulation • phosphatidylinositol-mediated signaling
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 9846 14389 Ensembl ENSG00000033327 ENSMUSG00000004508 UniProt Q9UQC2 Q3ZB57 RefSeq (mRNA) NM_012296.3 NM_001162477.1 RefSeq (protein) NP_036428.1 NP_001155949.1 Location (UCSC) Chr 11:
77.93 – 78.13 Mb Chr 7:
97.08 – 97.31 Mb PubMed search

GRB2-associated-binding protein 2 also known as GAB2 is a protein that in humans is encoded by the GAB2 gene.

GAB2 is a docking protein with a conserved, folded PH domain attached to the membrane and a large disordered region, which hosts interactions with signaling molecules. It is a member of the GAB/DOS family localized on the internal membrane of the cell. It mediates the interaction between receptor tyrosine kinases (RTKs) and non-RTK receptors serving as the gateway into the cell for activation of SHP2, Phosphatidylinositol 3-kinase (PI3K), Grb2, ERK, and AKT and acting as one of the first steps in these signaling pathways. GAB2 has been shown to be important in physiological functions such as growth in bone marrow and cardiac function. GAB2 has also been associated with many diseases including leukemia and Alzheimer's disease.