FYVE Domain
In molecular biology the FYVE zinc finger domain is named after the four cysteine-rich proteins: Fab 1 (yeast orthologue of PIKfyve), YOTB, Vac 1 (vesicle transport protein), and EEA1, in which it has been found. FYVE domains bind Phosphatidylinositol 3-phosphate, in a way dependent on its metal ion coordination and basic amino acids. The FYVE domain inserts into cell membranes in a pH dependent manner. The FYVE domain has been connected to vacuolar protein sorting and endosome function.
Famous quotes containing the words fyve and/or domain:
“Alle fresh the level pasture lay,
And not a shadowe mote by seene,
Save where full fyve good miles away
The steeple towered from out the greene,”
—Jean Ingelow (1820–1897)
“Every sign is subject to the criteria of ideological evaluation.... The domain of ideology coincides with the domain of signs. They equate with one another. Wherever a sign is present, ideology is present, too. Everything ideological possesses semiotic value.”
—V.N. (Valintin Nikolaevic)