Fyffe may refer to:
- Fyffe, Alabama, a town in DeKalb County, Alabama, in the United States
People with the surname Fyffe:
- Jahmaal Fyffe (b. 1990), English hip-hop rapper who has performed as Chip and as Chipmunk (rapper)
- Jim Fyffe (1945-2003), American sportscaster and radio talk show host
- Joseph P. Fyffe (1832-1896), American admiral
- Nick Fyffe (b. 1972), English musician
- Will Fyffe (1885-1947), Scottish actor, singer, and songwriter