Frank's Sign

Frank's sign or Frank sign is a diagonal ear lobe crease (ELC) extending diagonally from the tragus across the lobule to the rear edge of the auricle.

It has been hypothesised that Frank's sign is indicative of cardiovascular disease and/or diabetes. Some studies have described Frank's sign as a marker of cardiovascular disease but not linked to the severity of the condition. In contrast, other studies have rebutted any association between Frank's sign and coronary artery disease.

However, researchers do agree that these creases have no predictive value in Native American Indian and Asian patients.

Some studies have focused upon bilateral ELC.

The sign is named after Dr. Sanders T. Frank.

Read more about Frank's Sign:  Severity, Notable Individuals With Frank's Sign, Links To Images

Famous quotes containing the words frank and/or sign:

    Lizzie Borden took an axe
    And gave her mother forty whacks;
    When she saw what she had done,
    She gave her father forty-one.
    —Anonymous. Late 19th century ballad.

    The quatrain refers to the famous case of Lizzie Borden, tried for the murder of her father and stepmother on Aug. 4, 1892, in Fall River, Massachusetts. Though she was found innocent, there were many who contested the verdict, occasioning a prodigious output of articles and books, including, most recently, Frank Spiering’s Lizzie (1985)

    When politicians and politically minded people pay too much attention to literature, it is a bad sign—a bad sign mostly for literature.... But it is also a bad sign when they don’t want to hear the word mentioned.
    Italo Calvino (1923–1985)