Frank's sign or Frank sign is a diagonal ear lobe crease (ELC) extending diagonally from the tragus across the lobule to the rear edge of the auricle.
It has been hypothesised that Frank's sign is indicative of cardiovascular disease and/or diabetes. Some studies have described Frank's sign as a marker of cardiovascular disease but not linked to the severity of the condition. In contrast, other studies have rebutted any association between Frank's sign and coronary artery disease.
However, researchers do agree that these creases have no predictive value in Native American Indian and Asian patients.
Some studies have focused upon bilateral ELC.
The sign is named after Dr. Sanders T. Frank.
Read more about Frank's Sign: Severity, Notable Individuals With Frank's Sign, Links To Images
Famous quotes containing the words frank and/or sign:
“Chaste to her husband, frank to all beside,
A teeming mistress, but a barren bride.”
—Alexander Pope (1688–1744)
“For I choose that my remembrances of him should be pleasing, affecting, religious. I will love him as a glorified friend, after the free way of friendship, and not pay him a stiff sign of respect, as men do to those whom they fear. A passage read from his discourses, a moving provocation to works like his, any act or meeting which tends to awaken a pure thought, a flow of love, an original design of virtue, I call a worthy, a true commemoration.”
—Ralph Waldo Emerson (1803–1882)