Frank's sign or Frank sign is a diagonal ear lobe crease (ELC) extending diagonally from the tragus across the lobule to the rear edge of the auricle.
It has been hypothesised that Frank's sign is indicative of cardiovascular disease and/or diabetes. Some studies have described Frank's sign as a marker of cardiovascular disease but not linked to the severity of the condition. In contrast, other studies have rebutted any association between Frank's sign and coronary artery disease.
However, researchers do agree that these creases have no predictive value in Native American Indian and Asian patients.
Some studies have focused upon bilateral ELC.
The sign is named after Dr. Sanders T. Frank.
Read more about Frank's Sign: Severity, Notable Individuals With Frank's Sign, Links To Images
Famous quotes containing the words frank and/or sign:
“Angel: You are a sourpuss, aren’t you?
Brad: Yeah.
Angel: You want to bite somebody?
Brad: Yeah.
Angel: Well, pick your spot.”
—Fredric M. Frank (1911–1977)
“Hear, O Israel: The LORD is our God, the LORD alone; You shall love the LORD your God with all your heart, and with all your soul, and with all your might. Keep these words that I am commanding you today in your heart. Recite them to your children and talk about them when you are at home and when you are away, when you lie down and when you rise. Bind them as a sign on your hand, fix them as an emblem on your forehead, and write them on the doorposts of your house and on your gates.”
—Bible: Hebrew, Deuteronomy 6:4-9.