Health
Francine has suffered great brain damage, as Stan ran over her (twice) causing her brain to temporarily detach from her central nervous system. Though Roger restored the damage, she was left with severely reduced mental functions. Stan also accidentally erased the last 20 years of her memory (making Francine act like a teenager from 1985), which he managed to restore. Francine has told Steve that she used to stalk her old school teacher and she also willfully cut her own hand off when it was handcuffed to a pole so she could kill George Clooney (the hand was later reattached). Francine has two birth scars, a caesarian scar from Hayley's birth (although in "The Most Adequate Christmas Ever" Hayley's birth is show to be natural, albeit delivered by a baboon), and a scar on her perineum ("tore from V to A") from Steve's birth. Despite this, she claims in "Surro-Gate" that both of her own children's births were "a breeze" for her, and therefore becomes the natural choice to carry Greg and Terry's daughter for them. She also seems to have a case of empty nest syndrome, as she had problems coping with Steve's girlfriend, Debbie, and was more than willing to comfort Steve when Debbie broke up with him. This has recently begun to take obsessive levels, including Francine using a CIA anti-aging formula to turn Steve into a toddler that she could coddle and baby, and sabotaging his surprisingly successful attempts at popularity to keep him home (and also to keep him from possibly going into any potentially violent mood swings). It is also hinted that she has done cocaine in the past.
Read more about this topic: Francine Smith
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—Thomas Jefferson (1743–1826)