Langerhans Cells
Langerhans cells are immature dendritic cells that are found in all areas of the penile epithelium, but are most superficial in the inner surface of the foreskin. A study by Szabo and Short (2000) targets Langerhans cells as receptors of HIV, and states that these cells "must be regarded as the most probable sites for viral entry in primary HIV infection in men." Langerhans cells are also known to express the c-type lectin langerin, which may play a role in transmission of HIV to nearby lymph nodes. However, de Witte et al. (2007) argued that langerin, produced by Langerhans cells, blocks the transmission of HIV to T cells.
Read more about this topic: Foreskin
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